CDC2/CDK1 Products

Antibodies
CDC2/CDK1 [p Tyr15] Antibody
CDC2/CDK1 [p Tyr15] Antibody
AF888
Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Rabbit Polyclonal
CDC2/CDK1 [p Tyr15] Antibody
CDC2/CDK1 [p Tyr15] Antibody
NB500-142
Species: Hu, Xp, Mouse, Rat
Applications: WB
Host: Rabbit Polyclonal
Lysates
CDC2/CDK1 Overexpression Lysa ...
CDC2/CDK1 Overexpression Lysate (N...
NBL1-08991
Applications: WB
CDC2/CDK1 Overexpression Lysa ...
CDC2/CDK1 Overexpression Lysate (D...
H00000983-T02
Applications: WB
Proteins
CDC2/CDK1 Recombinant Protein ...
CDC2/CDK1 Recombinant Protein
H00000983-P01
Species: Hu
Applications: WB, ELISA, PA
CDC2/CDK1 Partial Recombinant ...
CDC2/CDK1 Partial Recombinant Protein
H00000983-Q01
Species: Hu
Applications: WB, ELISA, PA
CDC2/CDK1 Recombinant Protein ...
CDC2/CDK1 Recombinant Protein Antigen
NBP1-85729PEP
Species: Hu
Applications: AC
RNAi
CDC2/CDK1 RNAi
CDC2/CDK1 RNAi
H00000983-R04
Species: Hu
CDC2/CDK1 RNAi
CDC2/CDK1 RNAi
H00000983-R03
Species: Hu

Description

The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Rat
Product By Gene ID 983
Alternate Names
  • EC 2.7.11.23
  • p34 protein kinase
  • EC 2.7.11.22
  • Cell division protein kinase 1
  • cell cycle controller CDC2
  • Cell division control protein 2 homolog
  • P34CDC2
  • G1 to S and G2 to M
  • CDC28A
  • CDC2MGC111195
  • DKFZp686L20222
  • cyclin-dependent kinase 1

Research Areas for CDC2/CDK1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Core ESC-Like Genes
Mitotic Regulators
Phospho-Specific
Stem Cell Markers

Bioinformatics Tool for CDC2/CDK1

Discover related pathways, diseases and genes to CDC2/CDK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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