CD97 Products

Description

This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.

Bioinformatics

Entrez	976 Human
Uniprot	NP_001775
Product By Gene ID	976
Alternate Names	CD97 antigenseven-span transmembrane protein CD97 molecule Leukocyte antigen CD97 seven transmembrane helix receptor seven-transmembrane, heterodimeric receptor associated with inflammation TM7LN1

Research Areas for CD97

Find related products by research area and learn more about each of the different research areas below.

GPCR
Immunology