Species: Rt
Applications: Flow, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Po
Applications: Flow, IHC
Host: Mouse Monoclonal
Description
The CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species. The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
Bioinformatics
| Entrez |
Rat
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
5788 |
| Alternate Names |
- B220
- CD45 antigen
- CD45R
- EC 3.1.3.48
- L-CA
- LY5
- protein tyrosine phosphatase, receptor type, C
- receptor-type tyrosine-protein phosphatase C
- T200 glycoprotein
- T200 leukocyte common antigen
- T200receptor type, c polypeptide
|
