Applications: Flow, IHC, IHC-Fr, IHC-P, IP
Host: Mouse Monoclonal
The CD45 antigen is an essential regulator of leukocyte activation and development, and is now known to be a protein tyrosine phosphatase, e.g. CD45 is able to dephosphorylate the Src family of protein kinases. (1, 2) This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling and Fc receptor stimulation. (1, 2) The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variant CD45R, and as allelic forms CD45.1/Ly-5.1 and CD45.2/Ly-5.2. The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. (3, 4) The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD 45.1 allotype.
|Product By Gene ID
- EC 22.214.171.124
- T200 leukocyte common antigen
- T200 glycoprotein
- CD45 antigen
- receptor-type tyrosine-protein phosphatase C
- T200receptor type, c polypeptide
- protein tyrosine phosphatase, receptor type, C
Bioinformatics Tool for CD45.1
Discover related pathways, diseases and genes to CD45.1. Need help? Read the Bioinformatics Tool Guide
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