CD40/TNFRSF5 Products

Antibodies
CD40/TNFRSF5 Antibody [Unconj ...
CD40/TNFRSF5 Antibody [Unconjugated]
AF632
Species: Hu
Applications: WB, AgAct
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
CD40/TNFRSF5 Antibody
CD40/TNFRSF5 Antibody
NB100-56127
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
CD40/TNFRSF5 Antibody (82111) ...
CD40/TNFRSF5 Antibody (82111) [Unc...
MAB6321
Species: Hu
Applications: Flow, AgAct, ICC
Host: Mouse Monoclonal
Antibody Pairs
CD40/TNFRSF5 Antibody Pair
CD40/TNFRSF5 Antibody Pair
H00000958-AP41
Species: Hu
Applications: S-ELISA
ELISA Kits
CD40/TNFRSF5 ELISA Kit [Bioti ...
CD40/TNFRSF5 ELISA Kit [Biotin]
KA1062
Species: Hu, Mu
CD40/TNFRSF5 ELISA Kit
CD40/TNFRSF5 ELISA Kit
NBP1-91264
Species: Hu
Applications: ELISA
CD40/TNFRSF5 ELISA Kit [Bioti ...
CD40/TNFRSF5 ELISA Kit [Biotin]
KA1061
Species: Hu
Lysates
CD40/TNFRSF5 Overexpression L ...
CD40/TNFRSF5 Overexpression Lysate...
H00000958-T01
Species: Hu
Applications: WB
CD40/TNFRSF5 Overexpression L ...
CD40/TNFRSF5 Overexpression Lysate...
NBL1-08948
Applications: WB
Proteins
CD40/TNFRSF5 Recombinant Prot ...
CD40/TNFRSF5 Recombinant Protein A...
NBP2-33956PEP
Species: Hu
Applications: AC
CD40/TNFRSF5 Recombinant Prot ...
CD40/TNFRSF5 Recombinant Protein A...
NBP2-33957PEP
Species: Hu
Applications: AC
CD40/TNFRSF5 Recombinant Prot ...
CD40/TNFRSF5 Recombinant Protein
NBP2-51628
Species: Hu
Applications: PAGE
RNAi
CD40/TNFRSF5 RNAi
CD40/TNFRSF5 RNAi
H00000958-R03
Species: Hu
CD40/TNFRSF5 RNAi
CD40/TNFRSF5 RNAi
H00000958-R04
Species: Hu

Description

CD40 and its ligand CD154 are members of the tumor necrosis factor receptor (TNFR) and TNF families, respectively, that play key roles in signaling pathways mediating cell growth, survival and differentiation in B-lymphocytes (reviewed in Quezada et al 2004). The CD40 receptor is a 45-50 kDa glycoprotein and is expressed on the surface of B-lymphocytes, some activated T-cells, monocytes, follicular dendritic cells, basal epithelial cells, and in some epithelial and non-epithelial carcinomas. The functions of CD40 have been most extensively studied in B-cells. Ligation of B CD40 by CD154, expressed on activated T cells, stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. Several distinct structural motifs in the CD40 cytoplasmic domain regaulate various CD40 signaling pathways. A major CD40 signaling pathway activated from CD154 ligand binding is the canonical pathway to the transcription factor family NF-kB, a family of genes mediating immune and inflammatory responses. Although CD40 has been extensively studied as a plasma membrane-associated growth factor membrane receptor. it has also been identified in the cytoplasm and nucleus of normal and neoplastic B-lymphoid cells (Lin-Lee et al. 2006). Other growth factor receptors, including EGF, FGF, and TGF-B have also been identified in the nuclus. It is thought that plasma membrane receptor signaling may be followed by nuclear migration of signaling pathway components. The presence of CD40 in the nucleus of activated normal B lymphocytes and neoplastic B-lymphoid cells suggests that CD40 may play a more complex role in regulating essential growth and survival pathways in B-lymphocytes than previously thought.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 958
Alternate Names
  • MGC9013
  • CD40 antigen
  • CDW40
  • CDw40
  • CD40L receptor
  • tumor necrosis factor receptor superfamily member 5
  • B-cell surface antigen CD40
  • nerve growth factor receptor-related B-lymphocyte activation molecule
  • tumor necrosis factor receptor superfamily, member 5
  • CD40 type II isoform
  • p50
  • TNFRSF5CD40 antigen (TNF receptor superfamily member 5)
  • Bp50B cell-associated molecule
  • B cell surface antigen CD40
  • CD40 molecule, TNF receptor superfamily member 5

Research Areas for CD40/TNFRSF5

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Asthma
Cancer
Hematopoietic Stem Cell Markers
Immunology
Signal Transduction
Stem Cell Markers

Bioinformatics Tool for CD40/TNFRSF5

Discover related pathways, diseases and genes to CD40/TNFRSF5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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