CD40/TNFRSF5 Products

CD40/TNFRSF5 Antibody (G28-5) ...
CD40/TNFRSF5 Antibody (G28-5)
Species: Hu
Applications: Flow, Func, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
CD40/TNFRSF5 Antibody (mAb89) ...
CD40/TNFRSF5 Antibody (mAb89)
Species: Hu
Applications: Flow, Func, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
CD40/TNFRSF5 Antibody
CD40/TNFRSF5 Antibody
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Antibody Pairs
CD40/TNFRSF5 Antibody Pair [H ...
CD40/TNFRSF5 Antibody Pair [HRP]
Species: Hu
Applications: S-ELISA
Host: Monoclonal
Conjugate Catalog # Availability Size Price
Mouse CD40 Quantikine ELISA K ...
Mouse CD40 Quantikine ELISA Kit
Species: Mu
Applications: ELISA
Human CD40 Quantikine ELISA K ...
Human CD40 Quantikine ELISA Kit
Species: Hu
Applications: ELISA
Human CD40/TNFRSF5 DuoSet ELI ...
Human CD40/TNFRSF5 DuoSet ELISA, 5...
Species: Hu
Applications: ELISA
CD40/TNFRSF5 Overexpression L ...
CD40/TNFRSF5 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Mouse CD40/TNFRSF ...
Recombinant Mouse CD40/TNFRSF5 Fc ...
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human CD40/TNFRSF ...
Recombinant Human CD40/TNFRSF5 Fc ...
Species: Hu
Applications: Bioactivity
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Recombinant Cynomolgus Monkey ...
Recombinant Cynomolgus Monkey CD40...
Species: Pm-Cm
Applications: Bioactivity
Formulation Catalog # Availability Price  


CD40 and its ligand CD154 are members of the tumor necrosis factor receptor (TNFR) and TNF families, respectively, that play key roles in signaling pathways mediating cell growth, survival and differentiation in B-lymphocytes (reviewed in Quezada et al 2004). The CD40 receptor is a 45-50 kDa glycoprotein and is expressed on the surface of B-lymphocytes, some activated T-cells, monocytes, follicular dendritic cells, basal epithelial cells, and in some epithelial and non-epithelial carcinomas. The functions of CD40 have been most extensively studied in B-cells. Ligation of B CD40 by CD154, expressed on activated T cells, stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. Several distinct structural motifs in the CD40 cytoplasmic domain regaulate various CD40 signaling pathways. A major CD40 signaling pathway activated from CD154 ligand binding is the canonical pathway to the transcription factor family NF-kB, a family of genes mediating immune and inflammatory responses. Although CD40 has been extensively studied as a plasma membrane-associated growth factor membrane receptor. it has also been identified in the cytoplasm and nucleus of normal and neoplastic B-lymphoid cells (Lin-Lee et al. 2006). Other growth factor receptors, including EGF, FGF, and TGF-B have also been identified in the nuclus. It is thought that plasma membrane receptor signaling may be followed by nuclear migration of signaling pathway components. The presence of CD40 in the nucleus of activated normal B lymphocytes and neoplastic B-lymphoid cells suggests that CD40 may play a more complex role in regulating essential growth and survival pathways in B-lymphocytes than previously thought.


Entrez Human
Uniprot Human
Product By Gene ID 958
Alternate Names
  • MGC9013
  • CD40 antigen
  • CDW40
  • CDw40
  • CD40L receptor
  • tumor necrosis factor receptor superfamily member 5
  • B-cell surface antigen CD40
  • nerve growth factor receptor-related B-lymphocyte activation molecule
  • tumor necrosis factor receptor superfamily, member 5
  • CD40 type II isoform
  • p50
  • TNFRSF5CD40 antigen (TNF receptor superfamily member 5)
  • Bp50B cell-associated molecule
  • B cell surface antigen CD40
  • CD40 molecule, TNF receptor superfamily member 5

Research Areas for CD40/TNFRSF5

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Hematopoietic Stem Cell Markers
Signal Transduction
Stem Cell Markers

Bioinformatics Tool for CD40/TNFRSF5

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