CD40/TNFRSF5 Products

Description

CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.

Bioinformatics

Product By Gene ID

958

Alternate Names

B cell surface antigen CD40 B-cell surface antigen CD40 Bp50B cell-associated molecule CD40 antigen CD40 molecule, TNF receptor superfamily member 5 CD40 type II isoform CD40 CD40L receptor CDw40 MGC9013 nerve growth factor receptor-related B-lymphocyte activation molecule p50 TNFRSF5 TNFRSF5CD40 antigen (TNF receptor superfamily member 5) tumor necrosis factor receptor superfamily member 5 tumor necrosis factor receptor superfamily, member 5

Research Areas for CD40/TNFRSF5

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
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Cancer
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Signal Transduction