CD40/TNFRSF5 Products

Description

CD40 and its ligand CD154 are members of the tumor necrosis factor receptor (TNFR) and TNF families, respectively, that play key roles in signaling pathways mediating cell growth, survival and differentiation in B-lymphocytes (reviewed in Quezada et al 2004). The CD40 receptor is a 45-50 kDa glycoprotein and is expressed on the surface of B-lymphocytes, some activated T-cells, monocytes, follicular dendritic cells, basal epithelial cells, and in some epithelial and non-epithelial carcinomas. The functions of CD40 have been most extensively studied in B-cells. Ligation of B CD40 by CD154, expressed on activated T cells, stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. Several distinct structural motifs in the CD40 cytoplasmic domain regaulate various CD40 signaling pathways. A major CD40 signaling pathway activated from CD154 ligand binding is the canonical pathway to the transcription factor family NF-kB, a family of genes mediating immune and inflammatory responses. Although CD40 has been extensively studied as a plasma membrane-associated growth factor membrane receptor. it has also been identified in the cytoplasm and nucleus of normal and neoplastic B-lymphoid cells (Lin-Lee et al. 2006). Other growth factor receptors, including EGF, FGF, and TGF-B have also been identified in the nuclus. It is thought that plasma membrane receptor signaling may be followed by nuclear migration of signaling pathway components. The presence of CD40 in the nucleus of activated normal B lymphocytes and neoplastic B-lymphoid cells suggests that CD40 may play a more complex role in regulating essential growth and survival pathways in B-lymphocytes than previously thought.

Bioinformatics

Entrez	21939 Mouse 958 Human
Uniprot	AAH12419 Human AAH12419.1 Human AAH64518 Human NM_001250 Human NP_001241 Human NP_001241.1 Human P25942 Human P27512 Mouse
Product By Gene ID	958
Alternate Names	B cell surface antigen CD40 B-cell surface antigen CD40 Bp50B cell-associated molecule CD40 antigen CD40 molecule, TNF receptor superfamily member 5 CD40 type II isoform CD40L receptor CDW40 CDw40 MGC9013 nerve growth factor receptor-related B-lymphocyte activation molecule p50 TNFRSF5CD40 antigen (TNF receptor superfamily member 5) tumor necrosis factor receptor superfamily member 5 tumor necrosis factor receptor superfamily, member 5

Research Areas for CD40/TNFRSF5

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Asthma
Cancer
Hematopoietic Stem Cell Markers
Immunology
Signal Transduction
Stem Cell Markers