CCR9 Products

Description

CCR9 is encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. Two alternatively spliced transcript variants have been described.

Bioinformatics

Entrez	10803 Human 12769 Mouse
Uniprot	NP_006632 Human NP_112477.1 Human P51686 Human Q9WUT7 Mouse
Product By Gene ID	10803
Alternate Names	C-C chemokine receptor type 9 C-C CKR-9 CC-CKR-9 CCR-9 CDw199 antigen CDw199 chemokine (C-C motif) receptor 9 G protein-coupled receptor 28 GPR28 GPR-9-6G-protein coupled receptor 28

Research Areas for CCR9

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
GPCR
Immunology
Innate Immunity
Signal Transduction