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The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. Mayplay a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinonereductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various othero-quinones and p-quinones (in vitro)