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CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane of type II alveolar cells. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank">
Cathepsin E (CATE) is a gastric aspartyl protease member of the peptidase C1 family that functions as a disulfide-linked homodimer. Cathepsin E may have a role in immune function. It is most likely involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. Cathepsin E may also play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Cathepsin E is commonly linked to gastric cancer, and Cathepsin E antibodies have emerged as important reagents for gastric cancer studies.
