WB, ELISA, ICC/IF, IFHost:
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, ELISA, PA
Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-5 (ICH-3, ICEREL-III, TY protease) is a member of the caspase-1 subfamily and it is an upstream mediator of apoptosis. Caspase-5 is highly expressed in lung, liver, and skeletal muscle, and similar to Caspase-4, its overexpression can induce cellular apoptosis (1). A tetramer, Caspase-5 separates into two subunits of a 20kda (p20) and 10kda (p10) after activation. In vitro, Caspase-5 can be cleaved by GranB, a major player in Cytotoxic T lymphocytes (CTL) induced apoptosis (2). In vivo, the Caspase-5 expression is elevated by LPS and IFNg. Caspase-5 induced apoptosis can be inhibited by CrmA and Bcl-2. Caspase-5 has also been implicated in cellular inflammatory response and in the microsatelite mutator pathway for cancer (3).
|Product By Gene ID
- EC 3.4.22
- EC 188.8.131.52
- Protease TY
- TY protease
- Protease ICH-3
- caspase 5, apoptosis-related cysteine protease
- caspase 5, apoptosis-related cysteine peptidase
Research Areas for Caspase 5
Find related products by research area and learn more about each of the different research areas below.ApoptosisCancerCaspases
Bioinformatics Tool for Caspase 5
Discover related pathways, diseases and genes to Caspase 5. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
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