Caspase 5 Products

Antibodies
Caspase 5 Antibody
Caspase 5 Antibody
NBP1-77209
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IF
Host: Rabbit Polyclonal
Caspase 5 Antibody
Caspase 5 Antibody
NBP1-87682
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Kits
Caspase 5 Fluorometric Assay ...
Caspase 5 Fluorometric Assay Kit
KA0749
Species: Ma
Applications: Func
Caspase 5 Assay Kit
Caspase 5 Assay Kit
KA0750
Species: Ma
Applications: Func
Caspase 5 Assay Kit
Caspase 5 Assay Kit
KA0748
Species: Ma
Applications: Func
Lysates
Caspase 5 Overexpression Lysa ...
Caspase 5 Overexpression Lysate (N...
NBL1-08714
Applications: WB
Proteins
Caspase 5 Partial Recombinant ...
Caspase 5 Partial Recombinant Protein
H00000838-Q01
Species: Hu
Applications: WB, ELISA, PA
Caspase 5 Recombinant Protein ...
Caspase 5 Recombinant Protein Antigen
NBP1-87682PEP
Species: Hu
Applications: AC
Caspase 5 Peptide
Caspase 5 Peptide
NBP1-77209PEP
Species: Hu
Applications: AC
RNAi
Caspase 5 RNAi
Caspase 5 RNAi
H00000838-R01
Species: Hu

Description

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-5 (ICH-3, ICEREL-III, TY protease) is a member of the caspase-1 subfamily and it is an upstream mediator of apoptosis. Caspase-5 is highly expressed in lung, liver, and skeletal muscle, and similar to Caspase-4, its overexpression can induce cellular apoptosis (1). A tetramer, Caspase-5 separates into two subunits of a 20kda (p20) and 10kda (p10) after activation. In vitro, Caspase-5 can be cleaved by GranB, a major player in Cytotoxic T lymphocytes (CTL) induced apoptosis (2). In vivo, the Caspase-5 expression is elevated by LPS and IFNg. Caspase-5 induced apoptosis can be inhibited by CrmA and Bcl-2. Caspase-5 has also been implicated in cellular inflammatory response and in the microsatelite mutator pathway for cancer (3).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 838
Alternate Names
  • ICEREL-III
  • EC 3.4.22
  • ICE(rel)-III
  • ICH3
  • CASP-5
  • EC 3.4.22.58
  • Protease TY
  • TY protease
  • Protease ICH-3
  • caspase-5
  • caspase 5, apoptosis-related cysteine protease
  • MGC141966
  • ICE(rel)III
  • ICH-3
  • caspase 5, apoptosis-related cysteine peptidase

Research Areas for Caspase 5

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases

PTMs for Caspase 5

Learn more about PTMs related to Caspase 5.

Cleavage
Phosphorylation
Dephosphorylation
Methylation

Bioinformatics Tool for Caspase 5

Discover related pathways, diseases and genes to Caspase 5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Caspase 5 Blog Posts

Check out the latest blog posts on Caspase 5.
CARD & NFKB Antibodies for Apoptosis Research
Apoptosis is one of the main types of programmed cell death which involves a cascade of biochemical events leading to specific cell morphology characteristics and ultimately death of cells.Caspases play crucial roles in modulating cellular signaling...    Read more.
Caspase Antibodies as Cancer Biomarkers
We at Novus Biologicals are one of the leading antibody suppliers for products targeted to apoptosis. These products are regularly used by cancer research groups - apoptosis is fundamental to developing therapies that will kill tumor cells. Caspase pr...    Read more.
Read more Caspase 5 related blogs.