CARD8 Products

Antibodies
CARD8 Antibody
CARD8 Antibody
NB100-56181
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
CARD8 Antibody
CARD8 Antibody
NB100-56182
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
CARD8 Antibody
CARD8 Antibody
NBP2-47528
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
CARD8 Antibody Pair
CARD8 Antibody Pair
H00022900-AP22
Species: Hu
Applications: S-ELISA
Lysates
CARD8 Overexpression Lysate ( ...
CARD8 Overexpression Lysate (Denat...
H00022900-T01
Species: Hu
Applications: WB
CARD8 Overexpression Lysate ( ...
CARD8 Overexpression Lysate (Native)
NBP2-10259
Applications: WB
Proteins
CARD8 Partial Recombinant Pro ...
CARD8 Partial Recombinant Protein
H00022900-Q02
Species: Hu
Applications: WB, ELISA, PA
CARD8 Recombinant Protein
CARD8 Recombinant Protein
H00022900-P01
Species: Hu
Applications: WB, ELISA, PA
CARD8 Partial Recombinant Pro ...
CARD8 Partial Recombinant Protein
H00022900-Q01
Species: Hu
Applications: WB, ELISA, PA

Description

TUCAN (also known as CARD8 and CARDINAL) is a CARD domain containing protein. TUCAN stands for tumor-up-regulated CARD-containing antagonist of caspase nine. Proteins containing a CARD (caspase-associated recruitment domain) domain are key regulators of cell death, cell survival and cytokine production (reviewed in Damiano and Reed, 2004). CARD domains are found in the N-terminal pro-domains of certain caspases, a family of apoptotic and pro-inflammatory proteases, as well as in a diversity of other proteins including TUCAN. CARD domains are homotypic protein interaction motifs that enable networks of proteins to communicate via CARD-CARD interactions. TUCAN is an anti-apoptotic CARD protein that can protect tumors from cell death stimuli, and is overexpressed in certain forms of cancer. The role of TUCAN in tumor biology remains to be fully elucidated, and there appears to be be various mechanisms by TUCAN can potentially contribute to apoptosis resistance (reviewed in Checinska et al, 2006). For example, TUCAN has been shown to inhibit caspase-9 activation by binding to the CARD region of pro-caspase-9, thereby suppressing the formation of the Apaf-1-caspase-9 apoptotic complex and apoptosis. Additionally, a TUCAN isoform has been described that blocks both caspase-8 and caspase-9 mediated apoptosis. However, in some tumors, TUCAN does not appear to interact with caspase-9 and may play a role in modulating NF-kB transcription factor survivial signaling pathways. In this regard a CARD-independent interaction of TUCAN with Ikkg has been described, resulting in the inhibition of interleukin-1 and TNF-induced NF-kB activation. Human TUCAN is a 431 amino acid protein according to GenBank no. gi|14424229|sp|Q9Y2G2|CARD8_HUMAN, and migrates at ~45-49 kDa on SDS-PAGE.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 22900
Alternate Names
  • Dakar
  • CARD-inhibitor of NF-kappa-B-activating ligand
  • DACAR
  • tumor up-regulated CARD-containing antagonist of caspase nine
  • Tumor up-regulated CARD-containing antagonist of CASP9
  • caspase recruitment domain-containing protein 8
  • Apoptotic protein NDPP1
  • CARD inhibitor of NF-kappaB-activating ligands
  • NDPP
  • NDPP1MGC57162
  • CARDINALFLJ18121
  • TUCANFLJ18119
  • KIAA0955DKFZp779L0366
  • DAKAR
  • caspase recruitment domain family, member 8

Research Areas for CARD8

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for CARD8

Learn more about PTMs related to CARD8.

Phosphorylation
Cleavage

Bioinformatics Tool for CARD8

Discover related pathways, diseases and genes to CARD8. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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