CaMKIV Products

Description

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. Ca2+/calmodulin dependent protein kinase type 4 (CaMK4, formerly known as CaM kinase Gr) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase. CaMK4 is highly expressed in cell and tissue extracts such as the brain, lymphocytes, spleen, neurons, thymus and testes. This kinase has two isoforms, a catalytically active calmodulin dependent kinase or a testes specific calmodulin binding protein, calspermin, generated by alternative splicing from the same gene. CaMK4 appears to require another kinase (CaMKK) to stimulate it. CaMK4, in a calcium and calmodulin dependent manner, is implicated in phosphorylating transcription factors including the CCAAT enhancer binding protein (C/EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium dependent gene expression. In neurons, CaMK4 is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T cells (NFAT). CaMK4 is encoded, along with calspermin, by the CaMK4 gene. It has been found that in testes, CaMK4 is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

Bioinformatics

Product By Gene ID	814
Alternate Names	brain Ca(2+)-calmodulin-dependent protein kinase type IV brain Ca++-calmodulin-dependent protein kinase type IV calcium/calmodulin-dependent protein kinase IV calcium/calmodulin-dependent protein kinase type IV catalytic chain calcium/calmodulin-dependent protein kinase type IV CAM kinase- GR CAM kinase IV CaM kinase-GR CaMK IV caMK CaMK-GR EC 2.7.11 EC 2.7.11.17 IV MGC36771

Research Areas for CaMKIV

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific
Protein Kinase