CaMKII alpha/beta Products


Description

CaM KII is an important member of calcium/calmodulin-activated kinase, functioning in neural synaptic stimulation and T-cell receptor signaling. CaM KII has catalytic and regulatory domains. The binding of Ca++/calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase. The activated CaM KII further autophosphorylates itself at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaM KII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaM KII at Thr286. On the other hand, PKA (protein kinase A) prevents this phosphorylation process through its inhibitory effect on PP1.

Bioinformatics

Entrez Human
Mouse
Rat
Rat
Uniprot Rat
Product By Gene ID 815
Alternate Names
  • EC 2.7.11.17
  • EC 2.7.11
  • CaMK-II subunit alpha
  • CaMK-II alpha subunit
  • CaM kinase II subunit alpha
  • CaM-kinase II alpha chain
  • calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
  • CaM kinase II alpha subunit
  • CaMKIINalpha
  • CAMKAcalcium/calmodulin-dependent protein kinase type II subunit alpha
  • KIAA0968calcium/calmodulin-dependent protein kinase type II alpha chain
  • calcium/calmodulin-dependent protein kinase II alpha-B subunit
  • calcium/calmodulin-dependent protein kinase II alpha

Research Areas for CaMKII alpha/beta

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases
Wnt Signaling Pathway

PTMs for CaMKII alpha/beta

Learn more about PTMs related to CaMKII alpha/beta.

Phosphorylation
Cleavage
Dephosphorylation
Acetylation
Methylation
Palmitoylation
Ubiquitination
Myristoylation

Bioinformatics Tool for CaMKII alpha/beta

Discover related pathways, diseases and genes to CaMKII alpha/beta. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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