CaMKII alpha/beta Products

Description

CaM KII is an important member of calcium/calmodulin-activated kinase, functioning in neural synaptic stimulation and T-cell receptor signaling. CaM KII has catalytic and regulatory domains. The binding of Ca++/calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase. The activated CaM KII further autophosphorylates itself at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaM KII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaM KII at Thr286. On the other hand, PKA (protein kinase A) prevents this phosphorylation process through its inhibitory effect on PP1.

Bioinformatics

Entrez	815 Human 12325 Mouse 171140 Rat
Uniprot	P11275 Rat
Product By Gene ID	815
Alternate Names	calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha calcium/calmodulin-dependent protein kinase II alpha calcium/calmodulin-dependent protein kinase II alpha-B subunit CaM kinase II alpha subunit CaM kinase II subunit alpha CAMKAcalcium/calmodulin-dependent protein kinase type II subunit alpha CaMK-II alpha subunit CaMK-II subunit alpha CaMKIINalpha CaM-kinase II alpha chain EC 2.7.11 EC 2.7.11.17 KIAA0968calcium/calmodulin-dependent protein kinase type II alpha chain

Research Areas for CaMKII alpha/beta

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases
Wnt Signaling Pathway

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