CaMKII alpha/beta Products


CaM KII is an important member of calcium/calmodulin-activated kinase, functioning in neural synaptic stimulation and T-cell receptor signaling. CaM KII has catalytic and regulatory domains. The binding of Ca++/calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase. The activated CaM KII further autophosphorylates itself at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaM KII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaM KII at Thr286. On the other hand, PKA (protein kinase A) prevents this phosphorylation process through its inhibitory effect on PP1.


Entrez Human
Uniprot Rat
Product By Gene ID 815
Alternate Names
  • EC
  • EC 2.7.11
  • CaMK-II subunit alpha
  • CaMK-II alpha subunit
  • CaM kinase II subunit alpha
  • CaM-kinase II alpha chain
  • calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
  • CaM kinase II alpha subunit
  • CaMKIINalpha
  • CAMKAcalcium/calmodulin-dependent protein kinase type II subunit alpha
  • KIAA0968calcium/calmodulin-dependent protein kinase type II alpha chain
  • calcium/calmodulin-dependent protein kinase II alpha-B subunit
  • calcium/calmodulin-dependent protein kinase II alpha

Research Areas for CaMKII alpha/beta

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase
Signal Transduction
Tyrosine Kinases
Wnt Signaling Pathway

PTMs for CaMKII alpha/beta

Learn more about PTMs related to CaMKII alpha/beta.


Bioinformatics Tool for CaMKII alpha/beta

Discover related pathways, diseases and genes to CaMKII alpha/beta. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related CaMKII alpha/beta Blog Posts

Check out the latest blog posts on CaMKII alpha/beta.
CaMKII stimulates autophagic degradation of 'ID', a new frontier against cancer
By Yoskaly Lazo-Fernandez, PhD The field of Cancer Stem Cell (CSC) research has been gaining traction in recent years1. CSCs are a minority group of cells (usually about 1 in 10000) within solid tumors of hematolog...    Read more.
Read more CaMKII alpha/beta related blogs.