Calpain 10 Products

Description

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Bioinformatics

Entrez	11132 Human
Uniprot	NP_075571 Human NP_075571.1 Human
Product By Gene ID	11132
Alternate Names	Calcium-activated neutral proteinase 10 calpain 10 calpain-10 calpain-like protease CAPN10 CANP 10 CANP10 EC 3.4.22.- KIAA1845 NIDDM1