CACNA2D4 Products

Description

FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity.; Tissue specificity: Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level).; Subcellular location: Membrane; Single-pass type I membrane protein; Miscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.

Bioinformatics

Entrez	93589 Human
Uniprot	Q7Z3S7 Human
Product By Gene ID	93589
Alternate Names	calcium channel, voltage-dependent, alpha 2/delta subunit 4 RCD4 voltage-dependent calcium channel subunit alpha-2/delta-4 voltage-gated calcium channel alpha(2)delta-4 subunit Voltage-gated calcium channel subunit alpha-2/delta-4

Research Areas for CACNA2D4

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Vision