CACNA1A Products

Description

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; Tissue specificity: Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.

Bioinformatics

Entrez	773 Human
Uniprot	O00555 Human
Product By Gene ID	773
Alternate Names	Calcium channel, L type, alpha-1 polypeptide isoform 4 SCA6 CACN3 BI CACH4 Voltage-gated calcium channel subunit alpha Cav2.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A Brain calcium channel I calcium channel, L type, alpha-1 polypeptide HPCA brain calcium channel 1 FHM MHP1 EA2 MHP APCA CACNL1A4CAV2.1 Cav2.1 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Diseases related to CACNA1A

Discover more about diseases related to CACNA1A.

Ataxia
Migraine Disorders
Familial Hemiplegic Migraine
Ataxia, Spinocerebellar
Migraine With Aura
Cerebellar Ataxia
Episodic Ataxia Type 2 (disorder)
Spinocerebellar Ataxia Type 6 (disorder)
Epilepsy
Atrophy
Headache
Hemiplegia
Nystagmus
Channelopathies
Trinucleotide Repeat Expansion
Spinocerebellar Degeneration
Vertigo

Pathways for CACNA1A

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Pathogenesis
Synaptic Transmission
Cell Death
Reflex
Transport
Localization
Exocytosis
Ion Homeostasis
Aging
Hypersensitivity
Ion Transport
Methylation
Secretion
Cognition
Cell Proliferation
Dna Methylation
Muscle Contraction
Rna Splicing
Calcium Ion Homeostasis
Gene Silencing

PTMs for CACNA1A

Learn more about PTMs related to CACNA1A.

Phosphorylation
Methylation
Dephosphorylation

Bioinformatics Tool for CACNA1A

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