Species: Hu, Mu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: RNAi, RNAi SP
Species: Hu
Applications: RNAi, RNAi SP
Description
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; Tissue specificity: Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
773 |
| Alternate Names |
- Calcium channel, L type, alpha-1 polypeptide isoform 4
- SCA6
- CACN3
- BI
- CACH4
- Voltage-gated calcium channel subunit alpha Cav2.1
- voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Brain calcium channel I
- calcium channel, L type, alpha-1 polypeptide
- HPCA
- brain calcium channel 1
- FHM
- MHP1
- EA2
- MHP
- APCA
- CACNL1A4CAV2.1
- Cav2.1
- calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
|
Bioinformatics Tool for CACNA1A
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