CACNA1A Products


FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; Tissue specificity: Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.


Entrez Human
Uniprot Human
Product By Gene ID 773
Alternate Names
  • Calcium channel, L type, alpha-1 polypeptide isoform 4
  • SCA6
  • CACN3
  • BI
  • CACH4
  • Voltage-gated calcium channel subunit alpha Cav2.1
  • voltage-dependent P/Q-type calcium channel subunit alpha-1A
  • Brain calcium channel I
  • calcium channel, L type, alpha-1 polypeptide
  • HPCA
  • brain calcium channel 1
  • FHM
  • MHP1
  • EA2
  • MHP
  • APCA
  • CACNL1A4CAV2.1
  • Cav2.1
  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit


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