c-Abl Products

Description

c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.

Bioinformatics

Entrez	25 Human
Product By Gene ID	25
Alternate Names	Abelson murine leukemia viral oncogene homolog 1 ABL ABL1 bcr/abl BCR-ABL1 c-abl oncogene 1, non-receptor tyrosine kinase c-abl oncogene 1, receptor tyrosine kinase cAbl c-Abl EC 2.7.10 EC 2.7.10.2 JTK7 JTK7bcr/abl p150bcr/c-abl oncogene protein Proto-oncogene c-Abl proto-oncogene tyrosine-protein kinase ABL1 tyrosine-protein kinase ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl

Research Areas for c-Abl

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Cellular Markers
DNA Repair
Signal Transduction
Tumor Suppressors