Bmf Products

Antibodies
Bmf Antibody (6F3)
Bmf Antibody (6F3)
NBP2-46578
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
Bmf Antibody
Bmf Antibody
NBP1-76658
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Bmf Antibody
Bmf Antibody
NBP1-84660
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Bmf Overexpression Lysate (Na ...
Bmf Overexpression Lysate (Native)
NBL1-07996
Applications: WB
Proteins
Bmf Recombinant Protein Antig ...
Bmf Recombinant Protein Antigen
NBP1-84660PEP
Species: Hu
Applications: AC
Bmf Recombinant Protein
Bmf Recombinant Protein
NBC1-28000
Species: Hu
Applications: PAGE
Bmf Peptide
Bmf Peptide
NBP1-76658PEP
Species: Hu
Applications: AC

Description

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 90427
Alternate Names
  • bcl-2-modifying factor
  • FLJ00065
  • Bcl2 modifying factor

Research Areas for Bmf

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors

PTMs for Bmf

Learn more about PTMs related to Bmf.

Phosphorylation
Cleavage
Acetylation
Bromination
Demethylation
Glycosylation

Bioinformatics Tool for Bmf

Discover related pathways, diseases and genes to Bmf. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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