Band 3 Products

Band 3 Antibody (BIII 136)
Band 3 Antibody (BIII 136)
Species: Hu, Bv(-), Ca(-), Eq(-), Gp(-), Mu(-), Po(-)
Applications: WB, ELISA, ICC/IF, IP
Host: Mouse Monoclonal
Band 3 Antibody (2D5)
Band 3 Antibody (2D5)
Species: Hu
Applications: WB, ELISA, ICC/IF, S-ELISA
Host: Mouse Monoclonal
Band 3 Overexpression Lysate ...
Band 3 Overexpression Lysate (Dena...
Species: Hu
Applications: WB
Band 3 Overexpression Lysate ...
Band 3 Overexpression Lysate (Native)
Applications: WB
Band 3 Partial Recombinant Pr ...
Band 3 Partial Recombinant Protein
Species: Hu
Applications: WB, ELISA, PA
Band 3 Recombinant Protein An ...
Band 3 Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl
Band 3 Recombinant Protein An ...
Band 3 Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl
Band 3 RNAi
Band 3 RNAi
Species: Hu


The protein encoded by the Band 3 gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. (provided by RefSeq)


Entrez Human
Uniprot Human
Product By Gene ID 6521
Alternate Names
  • Solute carrier family 4 member 1
  • MGC116750
  • CD233 antigen
  • EMPB3
  • AE 1
  • BND3
  • Wright blood group
  • DI
  • Swann blood group
  • Anion exchanger 1
  • solute carrier family 4, anion exchanger, number 1
  • Anion exchange protein 1
  • Froese blood group
  • Waldner blood group
  • erythroid anion exchange protein
  • WR
  • erythrocyte membrane protein band 3
  • SW
  • band 3 anion transport protein
  • RTA1A
  • WD1
  • FR
  • WD
  • CD233
  • EPB3MGC126623
  • AE1MGC126619
  • MGC116753
  • solute carrier family 4, anion exchanger, member 1 (erythrocyte membraneprotein band 3, Diego blood group)

Research Areas for Band 3

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Bioinformatics Tool for Band 3

Discover related pathways, diseases and genes to Band 3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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