ATG4A Products

Antibodies
ATG4A Antibody
ATG4A Antibody
NBP1-89044
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
ATG4A Antibody (514914)
ATG4A Antibody (514914)
MAB4324
Species: Hu, Mu
Applications: WB, IP, ICC
Host: Mouse Monoclonal
ATG4A Antibody [Unconjugated] ...
ATG4A Antibody [Unconjugated]
AF4324
Species: Hu
Applications: WB, IP
Host: Sheep Polyclonal
Proteins
ATG4A Recombinant Protein Ant ...
ATG4A Recombinant Protein Antigen
NBP1-89044PEP
Species: Hu
Applications: AC
ATG4A Recombinant Protein
ATG4A Recombinant Protein
H00115201-P01
Species: Hu
Applications: WB, ELISA, PA

Description

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.; FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.; ENZYME REGULATION: Inhibited by N-ethylmaleimide; SUBCELLULAR LOCATION: Cytoplasm;

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 115201
Alternate Names
  • EC 3.4.22
  • AUT-like 2, cysteine endopeptidase (S. cerevisiae)
  • EC 3.4.22.-
  • APG4 autophagy 4 homolog A (S. cerevisiae)
  • Autophagin-2
  • hAPG4A
  • cysteine protease ATG4A
  • AUT-like 2 cysteine endopeptidase
  • autophagin-2
  • AUTL2
  • autophagin 2
  • APG4A
  • cysteine endopeptidase
  • ATG4 autophagy related 4 homolog A (S. cerevisiae)

Research Areas for ATG4A

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Phospho-Specific

PTMs for ATG4A

Learn more about PTMs related to ATG4A.

Cleavage
Phosphorylation
Reduction

Bioinformatics Tool for ATG4A

Discover related pathways, diseases and genes to ATG4A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ATG4A Blog Posts

Check out the latest blog posts on ATG4A.
ATG4A - protease that initiates ATG8 lipidation during autophagosome elongation
There are 3 major autophagy pathways- microautophagy, chaperone-mediated autophagy, and macroautophagy. Macroautophagy is the pathway herein referred to as simply autophagy. Autophagy can be broken down into 4 main stages: phagophore nucleatio...    Read more.
Read more ATG4A related blogs.