Ataxin-2 Products

Antibodies
Ataxin-2 Antibody
Ataxin-2 Antibody
NBP1-90063
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Ataxin-2 Antibody
Ataxin-2 Antibody
NBP1-90062
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Ataxin-2 Antibody
Ataxin-2 Antibody
NBP1-90064
Species: Hu, Mu, Rt, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Ataxin-2 Partial Recombinant ...
Ataxin-2 Partial Recombinant Protein
H00006311-Q01
Species: Hu
Applications: WB, ELISA, IP, PA
Ataxin-2 Recombinant Protein ...
Ataxin-2 Recombinant Protein Antigen
NBP1-90062PEP
Species: Hu
Applications: AC
Ataxin-2 Recombinant Protein ...
Ataxin-2 Recombinant Protein Antigen
NBP1-90064PEP
Species: Hu
Applications: AC
RNAi
Ataxin-2 RNAi
Ataxin-2 RNAi
H00006311-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 36-52 CAG repeats, compared to 22-23 in the normal allele. A potential transcript variant, missing an internal coding exon, has been described; however, its full-length nature is not certain.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 6311
Alternate Names
  • trinucleotide repeat containing 13
  • Trinucleotide repeat-containing gene 13 protein
  • ataxin-2
  • Spinocerebellar ataxia type 2 protein
  • SCA2FLJ46772
  • ataxin 2)
  • ATX2spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant
  • TNRC13
  • ataxin 2

Research Areas for Ataxin-2

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Hematopoietic Stem Cell Markers
Stem Cell Markers

PTMs for Ataxin-2

Learn more about PTMs related to Ataxin-2.

Phosphorylation
Cleavage
Methylation

Bioinformatics Tool for Ataxin-2

Discover related pathways, diseases and genes to Ataxin-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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