ASIP Products

Description

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq]

Bioinformatics

Product By Gene ID	434
Alternate Names	agouti (mouse)-signaling protein agouti signaling protein agouti signaling protein, nonagouti homolog (mouse) agouti signaling protein, nonagouti homolog Agouti switch protein agouti-signaling protein AGSW AGTI AGTIL AGTILMGC126092 ASIP ASPAGSW MGC126093 nonagouti homolog SHEP9

Research Areas for ASIP

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Signal Transduction