APIP Products

Description

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf-1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.

Bioinformatics

Entrez	51074 Human
Uniprot	NP_057041 Human NP_057041 Human AAH17594.1 Human AAH17594.1 Human Q96GX9 Human Q96GX9 Human NM_015957 Human NM_015957 Human
Product By Gene ID	51074
Alternate Names	MMRP19 EC 4.2.1.109 CGI29 probable methylthioribulose-1-phosphate dehydratase MTRu-1-P dehydratase dJ179L10.2 APAF1-interacting protein Mmrp19 APIP2 CGI-29 APAF1 interacting protein

Diseases related to APIP

Discover more about diseases related to APIP.

Hypoxia
Anoxia
Carcinoma
Malignant Neoplasms
Salmonella Infections
Cystic Fibrosis
Tongue Neoplasms
Cystic Fibrosis Lung
Tumor Progression
Neurodegenerative Disorders
Head And Neck Carcinoma
Lung Diseases
Malignant Neoplasm Of Lung
Inflammatory Response
Tongue Squamous Cell Carcinoma
Fibrosis
Neoplasms
Mammary Neoplasms
Neuroblastoma
Malignant Squamous Cell Neoplasm

Pathways for APIP

View related products by pathway and learn more about each of the pathways below.

Cell Death
Regulation Of Cell Death
Methylation
Neuroprotection
Programmed Cell Death
Dna Damage Checkpoint
Dna Methylation
Pyroptosis
Rna Interference
Inflammatory Response

PTMs for APIP

Learn more about PTMs related to APIP.

Phosphorylation
Cleavage
Methylation
Oxidation

Bioinformatics Tool for APIP

Discover related pathways, diseases and genes to APIP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.