APIP Products

Antibodies
Lysates
APIP Overexpression Lysate (N ...
APIP Overexpression Lysate (Native)
NBL1-07603
Applications: WB
Proteins
APIP Recombinant Protein Anti ...
APIP Recombinant Protein Antigen
NBP1-89040PEP
Species: Hu
Applications: AC
APIP Recombinant Protein Anti ...
APIP Recombinant Protein Antigen
NBP1-89039PEP
Species: Hu
Applications: AC
APIP Recombinant Protein
APIP Recombinant Protein
NBP1-98917
Species: Hu
Applications: PAGE

Description

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf-1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 51074
Alternate Names
  • MMRP19
  • EC 4.2.1.109
  • CGI29
  • probable methylthioribulose-1-phosphate dehydratase
  • MTRu-1-P dehydratase
  • dJ179L10.2
  • APAF1-interacting protein
  • Mmrp19
  • APIP2
  • CGI-29
  • APAF1 interacting protein

PTMs for APIP

Learn more about PTMs related to APIP.

Phosphorylation
Cleavage
Methylation
Oxidation

Bioinformatics Tool for APIP

Discover related pathways, diseases and genes to APIP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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