APIP Products

Description

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf-1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.

Bioinformatics

Entrez	51074 Human
Uniprot	AAH17594.1 Human AAH17594.1 Human NM_015957 Human NM_015957 Human NP_057041 Human NP_057041 Human Q96GX9 Human Q96GX9 Human
Product By Gene ID	51074
Alternate Names	APAF1 interacting protein APAF1-interacting protein APIP2 CGI29 CGI-29 dJ179L10.2 EC 4.2.1.109 MMRP19 Mmrp19 MTRu-1-P dehydratase probable methylthioribulose-1-phosphate dehydratase