Apc11 Products

Description

APC11 (anaphase-promoting complex subunit 11) is a member of the E3 enzyme family. This protein contains a RING-H2 domain and has a molecular weight of approximately 9.8 kD. The APC11 protein is distributed diffusely in the cytoplasm and is located in the nucleus with discrete accumulation in granular structures. The APC11 protein is a probable catalytic unit in the APC complex. The APC11 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC11 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. In addition to the APC complex proteins, APC11 has been shown to interact with Ubc4. The Poly6116 antibody has been shown to be useful for Western blotting of the human and mouse APC11 protein.

Bioinformatics

Entrez	51529 Human 66156 Mouse
Uniprot	AAH00607 Human AAH00607 Human NM_001002244 Human NM_001002244 Human NM_001002247 Human NM_001002247 Human NP_001002244 Human NP_001002244 Human NP_001002245 Human NP_001002245 Human NP_001002246 Human NP_001002246 Human NP_001002248 Human NP_001002248 Human NP_001002249 Human NP_001002249 Human NP_057560 Human NP_057560 Human Q9NYG5 Human Q9NYG5 Human
Product By Gene ID	51529
Alternate Names	anaphase promoting complex subunit 11 (yeast APC11 homolog) anaphase promoting complex subunit 11 anaphase-promoting complex subunit 11 APC11 anaphase promoting complex subunit 11 homolog APC11Hepatocellular carcinoma-associated RING finger protein Apc11p Cyclosome subunit 11 HSPC214 MGC882

Research Areas for Apc11

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Cell Cycle and Replication