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Antizyme inhibitor 1, or AZIN1 for short, consists of a 448 amino acid isoform that is 49 kDa, and is involved in the stabilization of ornithine decarboxylase antizymes, which help to regulate polyamine biosynthesis and homeostasis. Disease research is currently being conducted with AZIN1 and a variety of diseases and disorders to determine the relationship between the two. These diseases include Fanconi's anemia, malaria, liver cirrhosis, prostatitis, Hepatitis C, Hepatitis B, fibrosis, anemia, and prostate cancer. This protein interacts with OAZ2, FANCA, FANCC, OAZ1, and OAZ3 in processes linked to metabolism and regulation of catalytic activity.
