Anthrax LF Products



Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxicity to occur. It begins with the binding of PA to its cell-surface receptor, ATR (Anthrax Toxin Receptor), at which point PA is cleaved and the resulting 63 kD carboxyl-terminal fragment binds to LF and EF. LF is a protease that is known to cleave members of the mitogen-activated protein kinase kinase (MAPKK) family (2).


Alternate Names
  • Anthrax lethal factor
  • LF
  • Lef
  • bacillus anthracis lethal factor
  • B.anthracis lethal factor
  • Anthrax LF
  • Anthrax lethal toxin endopeptidase component

Research Areas for Anthrax LF

Find related products by research area and learn more about each of the different research areas below.

Virology, Bacteria and Parasites