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AMELX is a 191 amino acid protein that is most often secreted and involved in the process of forming enamel during tooth development due to expression in ameloblasts. Gene mutation can cause amelogenesis imperfect, and studies of this protein are being performed on research about dental fluorosis root resorption, dentiogenesis imperfect, dental fluorosis, purpura, thrombocytopenia, hyperparathyroidism, thrombocytopenia, hepatitis, periodontal disease pathways. This protein is known to have interaction with TMEM179B (transmembrane protein 179B), AHSG (Alpha-2-HS-glycoprotein), and FITM1 (Fat Storage-inducing transmembrane protein 1).
