AMBRA1 Products

Antibodies
AMBRA1 Antibody
AMBRA1 Antibody
26190002
Species: Hu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
AMBRA1 Antibody
AMBRA1 Antibody
NBP2-24723
Species: Hu, Mu, Rt, Bv, Ch
Applications: WB, IHC-P
Host: Rabbit Polyclonal
Lysates
AMBRA1 Overexpression Lysate ...
AMBRA1 Overexpression Lysate (Native)
NBP2-06932
Applications: WB
Proteins
AMBRA1 Recombinant Protein An ...
AMBRA1 Recombinant Protein Antigen
NBP2-32640PEP
Species: Hu
Applications: AC
AMBRA1 Blocking Peptide
AMBRA1 Blocking Peptide
NBP1-76894PEP
Species: Hu
Applications: AC
AMBRA1 Peptide
AMBRA1 Peptide
NBP1-76895PEP
Species: Hu
Applications: AC

Description

AMBRA1 regulates autophagy and development of the nervous system. It is a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. AMBRA1 is a positive regulator of the Becn1-dependent programme of autophagy, as revealed by its overexpression and by RNA interference experiments invitro. Notably, AMBRA1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Mouse
Product By Gene ID 55626
Alternate Names
  • WD repeat domain 94
  • WDR94
  • DDB1 and CUL4 associated factor 3
  • FLJ20294
  • activating molecule in BECN1-regulated autophagy protein 1
  • DCAF3
  • KIAA1736activating molecule in beclin-1-regulated autophagy
  • MGC33725
  • autophagy/beclin-1 regulator 1

Research Areas for AMBRA1

Find related products by research area and learn more about each of the different research areas below.

Autophagy

PTMs for AMBRA1

Learn more about PTMs related to AMBRA1.

Ubiquitination
Phosphorylation
Cleavage

Bioinformatics Tool for AMBRA1

Discover related pathways, diseases and genes to AMBRA1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related AMBRA1 Blog Posts

Check out the latest blog posts on AMBRA1.
Beclin 2, a mammal-specific homolog of Beclin 1 with unique functional similarities and differences
Beclin 2 (BECN2) is also called Beclin-1-like protein 1/ BECN1P1 and it was recently identified by He et al 2013 as a mammal-specific homolog of the evolutionarily conserved protein Beclin 1 which is well established for its role in the regulation...    Read more.
Read more AMBRA1 related blogs.