AMBRA1 Products

AMBRA1 Antibody
AMBRA1 Antibody
Species: Hu, Mu, Rt, Bv, Ch, Po, Ca, Pm, Pm, Ma-Op, Pm, Xp, Ze
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
AMBRA1 Antibody
AMBRA1 Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
AMBRA1 Overexpression Lysate
AMBRA1 Overexpression Lysate
Species: Hu
Applications: WB


AMBRA1 regulates autophagy and development of the nervous system. It is a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. AMBRA1 is a positive regulator of the Becn1-dependent programme of autophagy, as revealed by its overexpression and by RNA interference experiments invitro. Notably, AMBRA1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death.


Entrez Human
Uniprot Human
Product By Gene ID 55626
Alternate Names
  • WD repeat domain 94
  • WDR94
  • DDB1 and CUL4 associated factor 3
  • FLJ20294
  • activating molecule in BECN1-regulated autophagy protein 1
  • DCAF3
  • KIAA1736activating molecule in beclin-1-regulated autophagy
  • MGC33725
  • autophagy/beclin-1 regulator 1

Research Areas for AMBRA1

Find related products by research area and learn more about each of the different research areas below.



Learn more about PTMs related to AMBRA1.


Bioinformatics Tool for AMBRA1

Discover related pathways, diseases and genes to AMBRA1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related AMBRA1 Blog Posts

Check out the latest blog posts on AMBRA1.
Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch
By Christina Towers, PhD Mitophagy in the BrainSelective autophagic degradation of damaged mitochondria, known as mitophagy, has been described as a cyto-protective process. Accordingly, defects in mitophagy h...    Read more.
Animal Models to Study Autophagy
By Christina Towers, PhD What is autophagy?Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the...    Read more.
Beclin 2, a mammal-specific homolog of Beclin 1 with unique functional similarities and differences
Beclin 2 (BECN2) is also called Beclin-1-like protein 1/ BECN1P1 and it was recently identified by He et al 2013 as a mammal-specific homolog of the evolutionarily conserved protein Beclin 1 which is well established for its role in the regulation...    Read more.
Read more AMBRA1 related blogs.