Host: Rabbit Polyclonal
Applications: WB, ELISA, PA, AP
Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.
|Product By Gene ID
- homeobox protein aristaless-like 3
- Proline-rich transcription factor ALX3
- aristaless-like homeobox 3
- ALX homeobox 3
PTMs for ALX3
Learn more about PTMs related to ALX3.Methylation
Bioinformatics Tool for ALX3
Discover related pathways, diseases and genes to ALX3. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.