ALX3 Products

Antibodies
ALX3 Antibody
ALX3 Antibody
NB100-92297
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
ALX3 Antibody
ALX3 Antibody
NBP1-80285
Species: Mu
Applications: WB
Host: Rabbit Polyclonal
Proteins
ALX3 Partial Recombinant Prot ...
ALX3 Partial Recombinant Protein
H00000257-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
ALX3 RNAi
ALX3 RNAi
H00000257-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Mouse
Product By Gene ID 257
Alternate Names
  • homeobox protein aristaless-like 3
  • MGC141988
  • MGC138212
  • Proline-rich transcription factor ALX3
  • aristaless-like homeobox 3
  • ALX homeobox 3

PTMs for ALX3

Learn more about PTMs related to ALX3.

Methylation

Bioinformatics Tool for ALX3

Discover related pathways, diseases and genes to ALX3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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