ADAMTS18 Products

Description

ADAMTS18 (A disintegrin and metalloproteinase with thrombospondin motifs 18) is a 1,221 amino acid protein that is thought to function as a tumor suppressor. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS18 is downregulated in carcinoma cell lines by methylation of its promoter. Forced expression of ADAMTS18 in carcinoma cells can lead to significant inhibition of cell growth, suggesting that it plays a significant role as a tumor suppressor. Mutations in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2) and ADAMTS18 has also been linked to carotid artery occlusion, vitreoretinal degeneration, retinal detachment, myopia, cataracts, nasopharyngitis, pancreatic cancer, colorectal cancer, cerebritis breast cancer, melanoma and pancreatitis.

Bioinformatics

Entrez	170692 Human
Uniprot	NP_955387.1 Human Q8TE60 Human AAH63283.1 Human
Product By Gene ID	170692
Alternate Names	ADAM-TS 18 EC 3.4.24.82 ADAMTS21 EC 3.4.24.- ADAMTS-18 disintegrin and metalloprotease-like protein ADAM-TS18 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 21 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 18 A disintegrin and metalloproteinase with thrombospondin motifs 18 ADAM metallopeptidase with thrombospondin type 1 motif, 18

Diseases related to ADAMTS18

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Neoplasms
Carcinoma
Malignant Neoplasms
Thrombus
Neoplasm Metastasis
Melanoma
Malignant Tumor Of Colon
Congenital Cerebral Hernia
Hemorrhage
Retinal Detachment
Myopia
Colorectal Neoplasms
Cerebrovascular Accident
Colorectal Cancer
Severe Myopia
Tissue Adhesions
Thrombosis
Stomach Neoplasms

Pathways for ADAMTS18

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Methylation
Cell Adhesion
Cell Migration
Platelet Activation
Demethylation
Coagulation
Cell Cycle
Regulation Of Coagulation
Fibrinolysis
Cell Growth
Cell Recognition
Hemostasis
Secretion

PTMs for ADAMTS18

Learn more about PTMs related to ADAMTS18.

Cleavage
Methylation
Demethylation

Bioinformatics Tool for ADAMTS18

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