ADAMTS18 Products

Antibodies
ADAMTS18 Antibody - BSA Free
ADAMTS18 Antibody - BSA Free
NBP1-91651
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
ADAMTS18 Antibody
ADAMTS18 Antibody
NBP2-15285
Species: Hu, Bv
Applications: WB
Host: Rabbit Polyclonal
ADAMTS18 Antibody - BSA Free
ADAMTS18 Antibody - BSA Free
NBP1-57095
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
ELISA Kits
Human ADAMTS18 ELISA Kit (Col ...
Human ADAMTS18 ELISA Kit (Colorime...
NBP2-66442
Species: Hu
Applications: ELISA
Proteins
Recombinant Human ADAMTS18 GS ...
Recombinant Human ADAMTS18 GST (N-...
H00170692-Q01
Species: Hu
Applications: WB, ELISA, MA, AP
ADAMTS18 Recombinant Protein ...
ADAMTS18 Recombinant Protein Antigen
NBP1-91651PEP
Species: Hu
Applications: AC

Description

ADAMTS18 (A disintegrin and metalloproteinase with thrombospondin motifs 18) is a 1,221 amino acid protein that is thought to function as a tumor suppressor. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS18 is downregulated in carcinoma cell lines by methylation of its promoter. Forced expression of ADAMTS18 in carcinoma cells can lead to significant inhibition of cell growth, suggesting that it plays a significant role as a tumor suppressor. Mutations in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2) and ADAMTS18 has also been linked to carotid artery occlusion, vitreoretinal degeneration, retinal detachment, myopia, cataracts, nasopharyngitis, pancreatic cancer, colorectal cancer, cerebritis breast cancer, melanoma and pancreatitis.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 170692
Alternate Names
  • A disintegrin and metalloproteinase with thrombospondin motifs 18
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 18
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 21
  • ADAM metallopeptidase with thrombospondin type 1 motif, 18
  • ADAM-TS 18
  • ADAM-TS18
  • ADAMTS-18
  • ADAMTS21
  • disintegrin and metalloprotease-like protein
  • EC 3.4.24.-
  • EC 3.4.24.82