ADAMTS18 Products

Antibodies
ADAMTS18 Antibody
ADAMTS18 Antibody
NBP1-91651
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
ADAMTS18 Antibody
ADAMTS18 Antibody
NBP2-15285
Species: Hu, Bovine
Applications: WB
Host: Rabbit Polyclonal
ADAMTS18 Antibody
ADAMTS18 Antibody
NBP1-57095
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
ADAMTS18 Overexpression Lysat ...
ADAMTS18 Overexpression Lysate (De...
H00170692-T01
Species: Hu
Applications: WB
Proteins
ADAMTS18 Partial Recombinant ...
ADAMTS18 Partial Recombinant Protein
H00170692-Q01
Species: Hu
Applications: WB, ELISA, PA
ADAMTS18 Recombinant Protein ...
ADAMTS18 Recombinant Protein Antigen
NBP1-91651PEP
Species: Hu
Applications: AC
RNAi
ADAMTS18 RNAi
ADAMTS18 RNAi
H00170692-R02
Species: Hu
ADAMTS18 RNAi
ADAMTS18 RNAi
H00170692-R01
Species: Hu

Description

ADAMTS18 (A disintegrin and metalloproteinase with thrombospondin motifs 18) is a 1,221 amino acid protein that is thought to function as a tumor suppressor. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS18 is downregulated in carcinoma cell lines by methylation of its promoter. Forced expression of ADAMTS18 in carcinoma cells can lead to significant inhibition of cell growth, suggesting that it plays a significant role as a tumor suppressor. Mutations in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2) and ADAMTS18 has also been linked to carotid artery occlusion, vitreoretinal degeneration, retinal detachment, myopia, cataracts, nasopharyngitis, pancreatic cancer, colorectal cancer, cerebritis breast cancer, melanoma and pancreatitis.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 170692
Alternate Names
  • ADAM-TS 18
  • EC 3.4.24.82
  • ADAMTS21
  • EC 3.4.24.-
  • ADAMTS-18
  • disintegrin and metalloprotease-like protein
  • ADAM-TS18
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 21
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 18
  • A disintegrin and metalloproteinase with thrombospondin motifs 18
  • ADAM metallopeptidase with thrombospondin type 1 motif, 18

PTMs for ADAMTS18

Learn more about PTMs related to ADAMTS18.

Cleavage
Methylation
Demethylation

Bioinformatics Tool for ADAMTS18

Discover related pathways, diseases and genes to ADAMTS18. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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