Acetyl-CoA Carboxylase alpha/ACACA Products

Description

Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).

Bioinformatics

Entrez	107476 Mouse 31 Human 60581 Rat
Uniprot	NM_198834 Human NP_942131 Human Q13085 Human
Product By Gene ID	31
Alternate Names	ACACacetyl-CoA carboxylase 1 ACC1ACC ACCA ACC-alpha acetyl-CoA carboxylase alpha acetyl-Coenzyme A carboxylase alpha EC 6.4.1.2

Research Areas for Acetyl-CoA Carboxylase alpha/ACACA

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Lipid and Metabolism
Nutrient Sensing in the Brain
Phospho-Specific