A-Myb Products

Description

The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation and cellular growth through binding to promoters with the consensus sequence PyAAC(G/T)G and transactivating gene expression. c-Myb is the cellular homolog of the leukemogenic avian retroviral protein v-Myc. c-Myb is expressed predominantly in immature and rapidly dividing hematopoietic cells, and cellular levels of c-Myb substantially decreases as cells reach terminal differentiation. B-Myb is expressed in a wide variety of proliferating cells, with levels accumulating during the G1 to S phase transition. A-Myb is expressed at specific times in reproductive tissues, some neural cells, and a subset of normal and neoplastic B lymphocytes. Both A-Myb and B-Myb are expressed in t(14:18) lymphoma cells where they then inhibit cell arrest and apoptotic signaling. Expression of B-Myb rescues cells from p53-induced G1 phase arrest that is mediated by p21, while A-Myb functions as an anti-apoptotic factor by effectively activating the bcl-2 promoter and thereby up-regulating Bcl-2 expression.

Bioinformatics

Entrez	4603 Human
Product By Gene ID	4603
Alternate Names	A-MYB AMYBMGC120059 MGC120061 Myb-like protein 1 myb-related protein A v-myb avian myeloblastosis viral oncogene homolog-like 1 v-myb myeloblastosis viral oncogene homolog (avian)-like 1

Research Areas for A-Myb

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Cancer
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