5-Carboxylcytosine Products

Antibodies
5-Carboxylcytosine Antibody
5-Carboxylcytosine Antibody
NBP2-59148
Species: Hu, Mu, All-NA
Applications: DB, ICC/IF, IP, ICC/IF
Host: Rabbit Polyclonal

Description

5-carboxylcytosine (5caC) is the final oxidized derivative of 5-methylcytosine (5mC). 5mC is oxidized to 5-hydroxymethylcytosine (5hmC) which is then oxidized to 5-formylcytosine (5fC) then 5caC. Each of these oxidation steps are catalyzed by the Ten-Eleven Translocation (TET) family of enzymes. 5fC can then be further oxidized to 5-carboxylcytosine (5caC) by TET. Both 5fC and 5caC can be converted to unmodified cytosine by Terminal deoxynucleotidyl transferase (TdT) or Thymine DNA glycosylase (TDG) by base excision repair.

Bioinformatics

Alternate Names
  • 5-caC