c-Abl Products

Description

The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.Protein tyrosine kinases play important roles in the transduction of extracellular signals. Receptor tyrosine kinases include a myriad of growth factor receptors, which are activated upon ligand binding. Differential binding of adapter proteins may impart some signal specificity, since many of the receptors use the same adapter proteins, and may also link the activation of the receptor to multiple pathways. In contrast, nonreceptor tyrosine kinases are recruited to substrates and or activators by their SH2 and/or SH3 domains. These domains also allow them to interact with activated receptor tyrosine kinases. These kinases are divided into several groups, including the Src, Jak, Abl, Fak, Fps, Csk, Syk and Btk families, and are components of intracellular signaling cascades.

Bioinformatics

Entrez	25 Human 11350 Mouse 311860 Rat
Product By Gene ID	25
Alternate Names	Abelson murine leukemia viral oncogene homolog 1 ABL ABL1 bcr/abl BCR-ABL1 c-abl oncogene 1, non-receptor tyrosine kinase c-abl oncogene 1, receptor tyrosine kinase cAbl c-Abl EC 2.7.10 EC 2.7.10.2 JTK7 JTK7bcr/abl p150bcr/c-abl oncogene protein Proto-oncogene c-Abl proto-oncogene tyrosine-protein kinase ABL1 tyrosine-protein kinase ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl

Research Areas for c-Abl

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Cellular Markers
DNA Repair
Signal Transduction
Tumor Suppressors