c-Abl Products

Description

c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.

Bioinformatics

Entrez	11350 Mouse 25 Human 311860 Rat
Uniprot	NM_005157 Human NM_007313 Human NP_005148 Human NP_005148.2 Human NP_009297 Human P00519 Human Q9Y478 Human
Product By Gene ID	25
Alternate Names	Abelson murine leukemia viral oncogene homolog 1 ABL c-abl oncogene 1, non-receptor tyrosine kinase c-abl oncogene 1, receptor tyrosine kinase c-ABL EC 2.7.10 EC 2.7.10.2 JTK7bcr/abl p150bcr/c-abl oncogene protein Proto-oncogene c-Abl proto-oncogene tyrosine-protein kinase ABL1 tyrosine-protein kinase ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl

Research Areas for c-Abl

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Cytoskeleton Markers
DNA Repair
Phospho-Specific
Signal Transduction
Tumor Suppressors