Autophagy Pathway

Autophagy is a process of bulk protein degradation through an autophagosomic-lysosomal pathway. Autophagy can be divided into multiple subtypes: macroautophagy and microautophagy, specific and non-specific autophagy, as well as pexophagy, mitophagy and chaperone-mediated autophagy. Autophagy is important for differentiation, survival during nutrient deprivation and normal growth control. Links to cancer, hypoxia, and neurodegeneration have brought autophagy to the forefront of scientific studies in recent years. It now appears that autophagy’s ubiquitous role in cellular maintenance may mean that it plays some role in almost all diseases.

autophagy pathway

Explore Your Pathways With Novus Explorer! This free bioinformatics tool is designed to facilitate scientific exploration of related genes, diseases and pathways based on co-citations.

Novus Biologicals offers a variety of top quality antibodies and proteins for autophagy research. Some of our most popular autophagy research products are included below. Please follow the protein name links for more details.

Autophagy Targets

ULK1 ULK2 Atg2 Atg3
Atg4A, B, C, D Atg5 Beclin-1 Atg7
Apg8 GABARAP GABARAPL1/2
Atg9A Atg9B Atg10 Atg12
Atg13 Atg16L1 FIP200/ RB1CC1 WIPI-1, 2, 3, 4

 

Autophagy Regulators

mTOR pathway Class I PI3K S6K p38 MAPK
Class III PI3K Beclin-1 ERK1/2 TRAIL-R
TNF-R FADD JNK DAPK
DRP-1 Ceramide BNIP3 TFEB