ITGB1BP2

ITGB1BP2 is a muscle-specific protein cloned by a rat created by Branccio's group in Italy that was found to interact with the cytoplasmic domain of integrin beta 1¹. It is expressed only in heart and skeletal muscle but is not essential for normal development and differentiation of these tissues. Branccio's group published a follow-up study in Nature Medicine using an ITGB1BP2 antibody that the protein plays a critical role in sensing mechanical stress due to pressure overloading².