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BNIP3

BNIP3 - a regulator of mitochondrial autophagy and cell death

Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family members, BNIP3 binds to Bcl-2 and can activate the downstream effectors of Bax/Bak.