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Cyclin E antibody

Ku70's Roles in Double Strand and Mismatch DNA Repair

Ku70 is a 70 kDa protein that was shown to be involved in multiple cellular pathways, mainly involving DNA repair and recombination. Among these are the non-homologus end repairs of DNA double strand breaks. Ku70 was first identified as an autoantigen in the serum of patients with Scleroderma Ploymyosistosis Syndrome (1).