Aggrecanase

Aggrecan is essential for the normal function of articular cartilage and intervertebral discs. Aggrecan provides the ability for the tissues to withstand compressive loading. This property is dependent on both the high charge density endowed by its numerous chondroitin and keratan sulfate chains and its ability to form large molecular aggregates interacting with hyaluronans. Degradation of Aggrecan via the action of proteases takes place throughout life and the degradation products which accumulate in the tissue and impair its function.