Aggrecan Products

Description

Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.

Bioinformatics

Entrez	176 Human
Uniprot	P16112
Product By Gene ID	176
Alternate Names	ACAN AGC1 AGC1SEDK aggrecan core protein Aggrecan Cartilage-specific proteoglycan core protein Chondroitin sulfate proteoglycan 1 Chondroitin sulfate proteoglycan core protein 1 CSPCP CSPG1 CSPG1aggrecan 1 CSPGCP large aggregating proteoglycan MSK16 MSK16AGCAN SEDK

Research Areas for Aggrecan

Find related products by research area and learn more about each of the different research areas below.

Extracellular Matrix
Growth and Development
Mesenchymal Stem Cell Markers
Neuronal Cell Markers
Stem Cell Markers

Related Aggrecan Blog Posts

Check out the latest blog posts on Aggrecan.

Aches & Pains: Aggrecan in Joint Disease and Osteoarthritis Aggrecan is essential for the normal function of articular cartilage and intervertebral discs. Aggrecan provides the ability for the tissues to withstand compressive loading. This property is dependent on both the high charge density endowed by its nu...    Read more.

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