AMBRA1 Products

Description

AMBRA1 (Activating molecule in Beclin1-regulated autophagy protein 1, Kiaa1736, DCAF3) is a regulator of autophagy and neural development in embryogenesis. Ambra1 controls autophagy in the central nervous system by activating class III PtdIns3k complexes that are required for phagophore nucleation. Beclin1 and Vps34 interaction are promoted by AMBRA1, and help form this complex. The loss of AMBRA1 causes upregulated apoptosis and accumulation of ubiquitinated proteins, which finally proves lethal. It was recently discovered that AMBRA1 interacts with Parkin after prolonged mitochondrial depolarization, thus triggering mitophagy (PMID 21921694). AMBRA1 has 7 known isoforms, and numerous WD40 domains.

Bioinformatics

Entrez	55626 Human 228361 Mouse 59319 Rat
Uniprot	A2AH22 Mouse
Product By Gene ID	55626
Alternate Names	activating molecule in BECN1-regulated autophagy protein 1 autophagy/beclin-1 regulator 1 DCAF3 DDB1 and CUL4 associated factor 3 FLJ20294 KIAA1736activating molecule in beclin-1-regulated autophagy MGC33725 WD repeat domain 94 WDR94

Research Areas for AMBRA1

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Autophagy

Related AMBRA1 Blog Posts

Check out the latest blog posts on AMBRA1.

Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch By Christina Towers, PhD Mitophagy in the BrainSelective autophagic degradation of damaged mitochondria, known as mitophagy, has been described as a cyto-protective process. Accordingly, defects in mitophagy h...    Read more.

Animal Models to Study Autophagy By Christina Towers, PhD What is autophagy?Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the...    Read more.

Beclin 2, a mammal-specific homolog of Beclin 1 with unique functional similarities and differences Beclin 2 (BECN2) is also called Beclin-1-like protein 1/ BECN1P1 and it was recently identified by He et al 2013 as a mammal-specific homolog of the evolutionarily conserved protein Beclin 1 which is well established for its role in the regulation ...    Read more.

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