Zika virus (H/PF/2013) NS1 Antibody (990907) [Unconjugated]

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Recombinant Viral Zika Virus (H/PF/2013) NS1 protein was serially diluted 2-fold and captured by Mouse Anti-Viral Zika Virus (H/PF/2013) NS1 Monoclonal Antibody (Catalog # MAB99201) coated on a Clear Polystyrene ...read more

Product Details

Summary
Reactivity VSpecies Glossary
Applications ELISA
Clone
990907
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

Zika virus (H/PF/2013) NS1 Antibody (990907) [Unconjugated] Summary

Immunogen
Human embryonic kidney cell, HEK293-derived recombinant Viral Zika Virus (H/PF/2013) NS1
Val796 & Ser799-Ser1148, with a C-terminal 6-His tag
Accession # AHZ13508
Specificity
Detects Viral Zika Virus (H/PF/2013) NS1 in direct ELISAs
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Zika virus (H/PF/2013) NS1 Antibody (990907) [Unconjugated]

  • Zika Virus (H/PF/2013) NS1

Background

Zika Virus non-structural protein 1 (ZIKV NS1) is an approximately 48 kDa viral glycoprotein (1). Zika Virus is a mosquito-borne flavivirus and has been implicated an association with neonatal microcephaly and neurological disorders such as Guillain-Barré syndrome (2). ZIKV strain H/PF/2013 was isolated from human host.  ZIKV NS1 is a multifunctional virulence factor. The glycosylated NS1 exists as a membrane-associated dimer after translocation into the endoplasmic reticulum lumen, where it is essential for viral genome replication (1, 2). Infected cells secrete NS1 as a lipoprotein, which is involved in immune evasion and pathogenesis via interaction with components of the innate and adaptive immune systems (1, 2). Mature ZIKV NS1 contains 352 amino acids (aa) and has a hexameric conformation consisting of three dimers to form a symmetric barrel shape (1). It has high structural similarity to other flavivirus NS1 proteins, such as DENV and WNV (2, 3). Mature NS1 of ZIKV strain H/PF/2013 shares 98% aa sequence identity with NS1 of ZIKV strain MR 766 that was isolated from monkey host.
  1. Song, H. et al. (2016) Nat. Struct. and Mol. Biol. 23:456.
  2. Brown, WC. et al. (2016) Nat. Struct. and Mol. Biol. 23: 865.
  3. Baronti, C. et al. (2014) Genome Announc. 2: e00500

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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