Z-DNA Antibody

• Reactivity: Hu
• Applications: ICC/IF, IHC, IP
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated
• Concentration: 2.1 mg/ml

Z-DNA Antibody Summary

• Immunogen: Immunogen was brominated poly-(DG-DC)-left handed DNA (Z-DNA) complexed to methylated BSA
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200
  • Immunoprecipitation 8 ug/ml
• Application Notes: Use in ICC/IF reported in scientific literature (PMID:32200799).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 2.1 mg/ml
• Purity: Protein G purified

Alternate Names for Z-DNA Antibody

• DAI;DNA-dependent activator of IFN-regulatory factors;DNA-dependent activator of IRFs;RP4-718J7.1;Tumor stroma and activated macrophage protein DLM-1;Z-DNA-binding protein 1

Background

Z-DNA is one of the many possible double helical structures of DNA. It is a left-handed double helical structure in which the double helix winds to the left in a zig-zag pattern (instead of to the right, like the more common B-DNA form). Z-DNA is thought to be one of three biologically active double helical structures along with A- and B-DNA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Z-DNA Antibody (NB100-749)(3)

Publications using NB100-749

• Zhang W, Tanneti NS, Fausto A et al. The vaccinia virus E3L dsRNA binding protein detects distinct production patterns of exogenous and endogenous dsRNA bioRxiv : the preprint server for biology 2023-09-21 [PMID: 37790463] (ICC/IF, Human)
• Zhang T, Yin C, Boyd D et al. Influenza Virus Z-RNAs Induce ZBP1-MediatedNecroptosis Cell 2020-03-19 [PMID: 32200799] (ICC/IF, Mouse)
• Cerna A et al. Z-DNA, a new in situ marker for transcription. Eur J Histochem 48:49-56. 2004-01-01 [PMID: 15145775]