TLR12 Antibody [FITC]

Product Discontinued

TLR12 Antibody [FITC] Summary

• Immunogen: This antibody was developed against a synthetic peptide corresponding to amino acids of 743-756 (RVWLQGLRGKGDKG) of mouse TLR12.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TLR12P
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1ul/1 million cells

Reactivity Notes

This antibody is reactive to Mouse, Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for TLR12 Antibody [FITC]

• Gm1365
• TLR12
• toll-like receptor 12

Background

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TLR12 Antibody (NBP2-24832)(2)

Publications using NBP2-24832

• Palladino Michael A, Savarese Michael A, Chapman Jessica L et al. Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa. Am J Reprod Immunol. 2008-12-01 [PMID: 19032616]
• Palladino M A, Johnson T A, Gupta R et al. Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. Biol Reprod. 2007-06-01 [PMID: 17314314]

Bioinformatics

• Gene Symbol: TLR12P