Tiki2/TRABD2B Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, Flow
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 750

Tiki2/TRABD2B Antibody [Alexa Fluor® 750] Summary

• Immunogen: Human embryonic kidney cell line HEK293-derived transfected with human Tiki2/TRABD2B
  Accession # A6NFA1
• Specificity: Detects human Tiki2/TRABD2B in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tiki2/TRABD2B Antibody [Alexa Fluor® 750]

• HKAT
• Tiki2
• TRABD2B TraB domain containing 2B
• TRABD2B

Background

TIKI2, encoded by the TRABD2B gene, is a 517 aminoacid metalloproteinase that acts as a negative regulator of Wnt signaling by mediating the cleavage of N-terminal residues in many of Wnt proteins.  Tiki matalloproteins are dependent on Mn2+/Co2+ and are inhibited by divalent metal chelators like EDTA. The other known Tiki protein in human, Tiki1, is required for head formation via Wnt cleavage-oxidation and inactivation, but lacks known metalloprotease motifs. TIKI2 is upregulated in renal cell carcinoma and it appears to suppress growth of osteosarcoma by targeting the canonical Wnt pathway

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.