SSEA-3 Antibody (MC-631) [Alexa Fluor™ Plus 647]

• Reactivity: Hu, Mu
• Clone: MC-631
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 647

SSEA-3 Antibody (MC-631) [Alexa Fluor™ Plus 647] Summary

• Specificity: Recognizes a carbohydrate epitope of SSEA-3 (4, 5).
• Isotype: IgM
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SSEA-3 Antibody (MC-631) [Alexa Fluor™ Plus 647]

• SSEA3
• SSEA-3
• Stage specific embryonic antigen 3
• Stage-specific embryonic antigen 3

Background

SSEA-3, also known as glycolipid GB5, is expressed on the surface of human teratocarcinoma stem cells (EC), human embryonic germ cells (EG), and human embryonic stem cells (ES) (1). Expression of SSEA-3 is down regulated following differentiation of human EC cells. In contrast, the differentiation of murine EC and ES cells may be accompanied by an increase in SSEA-3 expression (2, 3).

1. Zhou, D. et al. (2000) J. Biol. Chem. 275:22631.
2. Thomson, J.A. and J.S. Odorico (2000) Trends Biotechnol. 18:53.
3. Draper, J.S. et al. (2002) J. Anat. 200:249.
4. Shevinsky, L.H. et al. (1982) Cell 30:697.
5. Kannagi, R. et al. (1983) EMBO J. 2:2355.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.