Quinacrine Inhibitor

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Quinacrine Inhibitor [NBP2-29385]
Quinacrine Inhibitor [NBP2-29385] - Evaluation of inhibitory activity of quinacrine. TLR9/NF-kB/SEAPorter™ HEK 293 and TLR2/NF-kB/SEAPorter™ HEK 293 cells were plated in 96-well plates at 5x10^4 cells/well ...read more
Quinacrine Inhibitor [NBP2-29385] - TLR9/NF-kB/SEAPorter™ HEK 293 cells were plated in 96-well plates at 5x10^4 cells/well for 16 h. Cells were preincubated with various concentrations of quinacrine for 30 min, ...read more

Product Details

Summary

Order Details

Quinacrine Inhibitor Summary

Immunogen
CAS Number 69-05-6
Empirical Formula (Hill Notation) C23H30ClN3O. 2HCl
Molecular Weight 472.88
Details of Functionality
Endosomal toll-like receptor inhibitor (antagonist); Inhibitor of endosomal acidification on which functional activity of endosomal TLRs (particularly TLR9 and TLR3) is dependent.

Applications/Dilutions

Application Notes
Assay>=90%

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Form : Yellow Solid (Powder)
Solubility:Deionized water

Alternate Names for Quinacrine Inhibitor

  • 1-2-bromophenyl-5-3-methylphenyl triazole-4-carboxylic acid
  • 6-Chloro-9-4-diethylamino-1-methylbutylamino-2-methoxyacridine dihydrochloride
  • Atebrin dihydrochloride
  • C23H30ClN3O-2HCl
  • Mepacrine dihydrochloride
  • Quinacrine dihydrochloride

Background

Quinacrine is a weak base which can partition into acidic vesicles such as endosomes and lysosomes, resulting in inhibition of endosomal acidification and lysosomal enzyme activity. Because acidic pH of endosomes is a prerequisite of endosomal TLR activation, quinacrine can serve as an antagonist for endosomal TLRs. Quinacrine and its analog chloroquine are also known to act as therapeutic agents for autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, of which therapeutic activity is due to suppression of TLR9 activity as shown by researchers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed for 1 year from date of receipt.

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