Quinacrine Inhibitor Summary
CAS Number 69-05-6
Empirical Formula (Hill Notation) C23H30ClN3O. 2HCl
Molecular Weight 472.88
|Details of Functionality
Endosomal toll-like receptor inhibitor (antagonist); Inhibitor of endosomal acidification on which functional activity of endosomal TLRs (particularly TLR9 and TLR3) is dependent.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Form : Yellow Solid (Powder)
Alternate Names for Quinacrine Inhibitor
- 1-2-bromophenyl-5-3-methylphenyl triazole-4-carboxylic acid
- 6-Chloro-9-4-diethylamino-1-methylbutylamino-2-methoxyacridine dihydrochloride
- Atebrin dihydrochloride
- Mepacrine dihydrochloride
- Quinacrine dihydrochloride
Quinacrine is a weak base which can partition into acidic vesicles such as endosomes and lysosomes, resulting in inhibition of endosomal acidification and lysosomal enzyme activity. Because acidic pH of endosomes is a prerequisite of endosomal TLR activation, quinacrine can serve as an antagonist for endosomal TLRs. Quinacrine and its analog chloroquine are also known to act as therapeutic agents for autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, of which therapeutic activity is due to suppression of TLR9 activity as shown by researchers.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed
for 1 year from date of receipt.
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