Quinacrine Products

Description

Quinacrine is a weak base which can partition into acidic vesicles such as endosomes and lysosomes, resulting in inhibition of endosomal acidification and lysosomal enzyme activity. Because acidic pH of endosomes is a prerequisite of endosomal TLR activation, quinacrine can serve as an antagonist for endosomal TLRs. Quinacrine and its analog chloroquine are also known to act as therapeutic agents for autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, of which therapeutic activity is due to suppression of TLR9 activity as shown by researchers.

Bioinformatics

Alternate Names

1-2-bromophenyl-5-3-methylphenyl triazole-4-carboxylic acid 6-Chloro-9-4-diethylamino-1-methylbutylamino-2-methoxyacridine dihydrochloride Atebrin dihydrochloride C23H30ClN3O-2HCl Mepacrine dihydrochloride Quinacrine dihydrochloride