Progesterone Antibody

Immunohistochemistry-Paraffin: Progesterone Antibody [NB100-65167] - Immunoperoxidase staining of paraffin embedded human ovary tissue with NB100-65167.

Product Discontinued

Progesterone Antibody Summary

• Immunogen: Progesterone conjugated to BSA
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:50
  • Immunohistochemistry-Paraffin 1:50

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 5.0 mg/ml
• Purity: Protein G purified

Alternate Names for Progesterone Antibody

• 4-Pregnen-3,20-dione
• Progesterone

Background

Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Progesterone receptor, a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. Although PRA and PRB share several structural domains, they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap. It is composed of three domains: a modulating N terminal domain, a DNA binding domain and a C terminal steroid binding domain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Progesterone Antibody (NB100-65167)(1)

Publication using NB100-65167

• Maddahi A, Warfvinge K, Holm A et al. Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex The journal of headache and pain 2023-11-14 [PMID: 37957603] (IHC-P, Rat)
  
  Details:
  1:50 IHC-P dilution