Human Osteosarcoma Tissue MicroArray

Product Discontinued

Human Osteosarcoma Tissue MicroArray Summary

• Description: Microarray Panel:
  Osteosarcoma
  No. of samples: 60
  No. of patients: 60
  Core diameter: 2.0 mm
  Format: Formalin Fixed
  Section thickness: 4 micrometer
  Please see manual for tissue information and location.
  
  All tissues are fixed in 10% neutral buffered formalin for 12 to 24 hours, dehydrated with gradient ethanol, cleared with xylene, and embedded in paraffin. Then each slide is tested for immunohistochemistry on multiple antibodies including the p53 protein. Quality control is ensured as every tissue block is collected and arranged by certified pathologists, who used an identical process for their own research.
  
  About 100,000 cells are included in each sample with 2 mm core diameter. Some slides may have less than 60 cores due to sample loss when obtaining multiple sections. Maximum number of missing cores in a slide is less than 10%.

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.

Details for Array

• Type: Tissue

Alternate Names for Human Osteosarcoma Tissue MicroArray

• Osteosarcomas

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Tissue Micro Arrays are guaranteed for 1 year from date of receipt.

Publications for Osteosarcoma Tissue Micro Array (NBP2-30289)(12)

Publications using NBP2-30289

• Hirozane T, Masuda M, Sugano T, et al. Direct conversion of osteosarcoma to adipocytes by targeting TNIK JCI insight 2021-01-05 [PMID: 33400690]
• Linder M, Glitzner E, Srivatsa S et al. EGFR is required for FOS-dependent bone tumor development via RSk2/CREB signaling. EMBO Mol Med. 2018-10-25 [PMID: 30361264] (IF/IHC, Human)
• Daft PG, Yuan K, Warram JM et al. Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma. Mol Cancer Res. 2013-04-01 [PMID: 23364534] (IHC-P)
  
  Details:
  IHC (paraffin), Fig 1. IMH-370 osteosarcoma TMA slides were stained with H&E or with H&E plus a a-CaMkII antibody.
• Yang W, Liu X, Choy E et al. Targeting hedgehog-GLI-2 pathway in osteosarcoma. J Orthop Res. 2013-03-01 [PMID: 22968906] (IHC-P)
  
  Details:
  IHC (paraffin), Fig 7. The IMH-370 osteosarcoma TMA slide was stained with a GLI-2 antibody.
• DAFT PG Zayzafoon M. et al. ALPHA-CaMKII-INDUCED VEGF EXPRESSION IS CRITICAL FOR THE GROWTH OF HUMAN OSTEOSARCOMA Thesis 2015-01-01 (IHC-P)
• Duan Z, Zhang J, Choy E et al. Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. Clin Cancer Res. 2012-09-01 [PMID: 22791884] (IHC-P)
  
  Details:
  IHC (paraffin), Fig 4. The IMH-370 osteosarcoma TMA slide was stained with a CDk11 antibody.
• Liu X, Choy E, Hornicek FJ et al. ROCK1 as a potential therapeutic target in osteosarcoma. J Orthop Res. 2011-08-01 [PMID: 21387396] (IHC-P)
  
  Details:
  IHC (paraffin), Fig 6. The IMH-370 osteosarcoma TMA slide was stained with a ROCk1 antibody.
• Susa M, Choy E, Liu X et al. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. Mol Cancer Ther. 2010-12-01 [PMID: 20881269] (IHC-P)
  
  Details:
  IHC (paraffin), Fig 5, Table I. The IMH-370 osteosarcoma TMA slide was stained with a Cyclin G antibody.
• Duan Z, Ji D, Weinstein EJ et al. Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. Cancer Lett. 2010-07-28 [PMID: 20144850] (IHC-P)
  
  Details:
  IHC (paraffin), Fig 5. The IMH-370 osteosarcoma TMA slide was stained with a PLk1 antibody.
• Ryu K, Choy E, Yang C et al. Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. J Orthop Res. 2010-07-01 [PMID: 20063378] (IHC-P)
  
  Details:
  IHC (paraffin), Figs 2,3 & Tables 1,2. The IMH-370 osteosarcoma TMA slide was stained with a phospho-STAT3 antibody.
• Yang C, Ji D, Weinstein EJ et al. The kinase Mirk is a potential therapeutic target in osteosarcoma. Carcinogenesis. 2010-04-01 [PMID: 20042639] (IHC-P)
  
  Details:
  IHC (paraffin), Fig 5, Table 1. The IMH-370 osteosarcoma TMA slide was stained with a MIRk antibody.
• Deshpande AM, Akunowicz JD, Reveles XT et al. PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. Oncogene. 2007-03-15 [PMID: 17001316] (IHC-P)
  
  Details:
  IHC (paraffin), Fig. 5.

FAQs for Osteosarcoma Tissue Micro Array (NBP2-30289). (Showing 1 - 1 of 1 FAQs).

1. Can we have a copy of the patient clinical data on microtissue array product of NBP2-30289, also it the data allowed to be published?
   • All known information about the patient donors is located on our website datasheets. Any of this information can be published. Please note that there is no other information available for these patients beyond the attached survival data that will come with your datasheet upon ordering.