Nitrotyrosine Antibody (11C2)

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Product Details

Summary
Reactivity AllSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clone
11C2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

Nitrotyrosine Antibody (11C2) Summary

Immunogen
KLH-Nitrotyrosine
Specificity
The mouse monoclonal reacts with free and bound Nitrotyrosine
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:500
  • ELISA 1:100-1:1000
  • Immunocytochemistry/Immunofluorescence 1:100-1:500
  • Immunohistochemistry 1:100-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

There is no cross reaction with free or bound Tyrosine.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Cell culture supernatant
Preservative
0.02% Sodium Azide
Concentration
LYOPH
Purity
Unpurified
Reconstitution Instructions
Reconstitute with 1.0 ml distilled water.

Alternate Names for Nitrotyrosine Antibody (11C2)

  • Nitrotyrosine

Background

Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A, SP-A, to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimers disease, Parkinsons disease and amyotrophic lateral sclerosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Nitrotyrosine Antibody (NB100-57383) (0)

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Secondary Antibodies

 

Isotype Controls

Additional Nitrotyrosine Products

Nitrotyrosine NB100-57383

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